In the design of high speed circuit, the data transmission speed is very fast and the electronic components work noise margin is very small, therefore It is an enormous challenge to get a well-regulated power supply. This paper introduces the emulation design and analysis of power integrity and signal integrity of high-speed circuit boards, packages and high-speed serial links. Based on the simulation tool, the problem for the power supply of whole circuit and key signal line are taken as the research obiects. The practice has proved that emulation used simulation tool can speed design, improve the success of circuit boards and decrease cost.